Bulletin of
Vitebsk State
Technological
University

Abstract

The creation of new types of highly effective wound coverings and dressings is an urgent task. The article is devoted to the development and investigation of wound-healing materials consisting of a sorbent substrate and a nanofibrous coating obtained by electrospinning. Nonwoven spunlace was chosen as the substrate, and its sorption properties were enhanced by impregnation with a sodium alginate solution. The nanofibrous coating was formed from a solution of chitosan and polyvinyl alcohol. The rational composition of the spinning solution and operating modes of the Fluidnatek LE-50 that ensure the stability of the electrospinning process were determined. Analysis of SEM images of the structure of the samples showed that the resulting nanofibrous coatings were distinguished by the uniformity of nanofiber deposition and a small number of defects. An assessment of the healing properties of sorbent wound nanofibrous coatings was carried out based on the study of the regeneration processes of full-thickness skin wounds in mature nonlinear white rats. Data from histological studies indicate accelerated epithelization of primarily contaminated skin wounds when using chitosan-alginate wound dressings. This is confirmed by the accelerated epithelization of the wound surface, the formation of a more powerful layer of the epidermis, the establishment of its closer connections with the developing dermis, the accelerated development of the dermis, and the less severe inflammatory processes in the wound.

Development of a wound-healing sorbent material with a nanofiber coating